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Article

Aristolochic acid exposure in Romania and implications for renal cell carcinoma.

British journal of cancer - 12 Jan 2016

Turesky Robert J, Yun Byeong Hwa, Brennan Paul, Mates Dana, Jinga Viorel, Harnden Patricia, Banks Rosamonde E, Blanche Helene, Bihoreau Marie-Therese, Chopard Priscilia, Letourneau Louis, Lathrop G Mark, Scelo Ghislaine

Abstract excerpt

BACKGROUND: Aristolochic acid (AA) is a nephrotoxicant associated with AA nephropathy (AAN) and upper urothelial tract cancer (UUTC). Whole-genome sequences of 14 Romanian cases of renal cell carcinoma (RCC) recently exhibited mutational signatures consistent with AA exposure, although RCC had not been previously linked with AAN and AA exposure was previously reported only in localised rural areas. METHODS: We...

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Identifiers

PMID: 26657656
DOI: 10.1038/bjc.2015.402
PMCID: PMC4716534

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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