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Article

Semi-Lethal Primary Ciliary Dyskinesia in Rats Lacking the Nme7 Gene.

International journal of molecular sciences - 7 Apr 2021

Šedová Lucie, Buková Ivana, Bažantová Pavla, Petrezsélyová Silvia, Prochazka Jan, Školníková Elena, Zudová Dagmar, Včelák Josef, Makovický Pavol, Bendlová Běla, Šeda Ondřej, Sedlacek Radislav

Abstract excerpt

NME7 (non-metastatic cells 7, nucleoside diphosphate kinase 7) is a member of a gene family with a profound effect on health/disease status. NME7 is an established member of the ciliome and contributes to the regulation of the microtubule-organizing center. We aimed to create a rat model to further investigate the phenotypic consequences of Nme7 gene deletion. The CRISPR/Cas9 nuclease system was used for the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 33916973
DOI: 10.3390/ijms22083810
PMCID: PMC8067621

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