Article
Mutant PKCγ in spinocerebellar ataxia type 14 disrupts synapse elimination and long-term depression in Purkinje cells in vivo.
The Journal of neuroscience : the official journal of the Society for Neuroscience - 5 Oct 2011
Shuvaev Anton N, Horiuchi Hajime, Seki Takahiro, Goenawan Hanna, Irie Tomohiko, Iizuka Akira, Sakai Norio, Hirai Hirokazu
Abstract excerpt
Cerebellar Purkinje cells (PCs) express a large amount of the γ isoform of protein kinase C (PKCγ) and a modest level of PKCα. The PKCγ is involved in the pruning of climbing fiber (CF) synapses from developing PCs, and PKCα plays a critical role in long-term depression (LTD) at parallel fiber (PF)-PC synapses. Moreover, the PKC signaling in PCs negatively modulates the nonselective transient receptor potential...
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