Article
Abnormal features in mutant cerebellar Purkinje cells lacking junctophilins.
Biochemical and biophysical research communications - 23 Nov 2007
Ikeda Atsushi, Miyazaki Taisuke, Kakizawa Sho, Okuno Yasushi, Tsuchiya Soken, Myomoto Akira, Saito Shin-ya, Yamamoto Tetsuji, Yamazaki Tetsuo, Iino Masamitsu, Tsujimoto Gozoh, Watanabe Masahiko, Takeshima Hiroshi
Abstract excerpt
Junctional membrane complexes (JMCs) generated by junctophilins are required for Ca(2+)-mediated communication between cell-surface and intracellular channels in excitable cells. Knockout mice lacking neural junctophilins (JP-DKO) show severe motor defects and irregular cerebellar plasticity due...
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