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Article

Phenotypic heterogeneity in modeling cancer evolution.

PloS one - 1 Jan 2017

Mahdipour-Shirayeh Ali, Kaveh Kamran, Kohandel Mohammad, Sivaloganathan Sivabal

Abstract excerpt

The unwelcome evolution of malignancy during cancer progression emerges through a selection process in a complex heterogeneous population structure. In the present work, we investigate evolutionary dynamics in a phenotypically heterogeneous population of stem cells (SCs) and their associated progenitors. The fate of a malignant mutation is determined not only by overall stem cell and non-stem cell growth rates...

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Identifiers

PMID: 29084232
DOI: 10.1371/journal.pone.0187000
PMCID: PMC5662227

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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