Article
Variant rs10911021 that associates with coronary heart disease in type 2 diabetes, is associated with lower concentrations of circulating HDL cholesterol and large HDL particles but not with amino acids.
Cardiovascular diabetology - 22 Aug 2016
Beaney Katherine E, Cooper Jackie A, McLachlan Stela, Wannamethee S Goya, Jefferis Barbara J, Whincup Peter, Ben-Shlomo Yoav, Price Jacqueline F, Kumari Meena, Wong Andrew, Ong Ken, Hardy Rebecca, Kuh Diana, Kivimaki Mika, Kangas Antti J, Soininen Pasi, Ala-Korpela Mika, Drenos Fotios, Humphries Steve E
Abstract excerpt
AIMS: An intergenic locus on chromosome 1 (lead SNP rs10911021) was previously associated with coronary heart disease (CHD) in type 2 diabetes (T2D). Using data from the UCLEB consortium we investigated the relationship between rs10911021 and CHD in T2D, whether rs10911021 was associated with levels of amino acids involved in the γ-glutamyl cycle or any conventional risk factors (CRFs) for CHD in the T2D...
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