Article
Putative association between a new polymorphism in exon 3 (Arg109Cys) of the pancreatic colipase gene and type 2 diabetes mellitus in two independent Caucasian study populations.
Molecular nutrition & food research - 1 Oct 2005
Lindner Inka, Helwig Ulf, Rubin Diana, Li Yun, Fisher Eva, Boeing Heiner, Möhlig Matthias, Spranger Joachim, Pfeiffer Andreas, Hampe Jochen, Schreiber Stefan, Döring Frank, Schrezenmeir Jürgen
Abstract excerpt
The protein encoded by the pancreatic colipase (CLPS) gene is an essential cofactor needed by pancreatic triglyceride lipase (PNLIP) for efficient dietary lipid hydrolysis. Since the inhibition of lipase activity was shown to reduce the incidence of type 2 diabetes mellitus, we tested the hypothesis that genetic variations in the CLPS and PNLIP genes are associated with type 2 diabetes; 47 unrelated subjects were...
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