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Exploiting replicative stress in gynecological cancers as a therapeutic strategy

23 Jun 2020

Abstract excerpt

Elevated levels of replicative stress in gynecological cancers arising from uncontrolled oncogenic activation, loss of key tumor suppressors, and frequent defects in the DNA repair machinery are an intrinsic vulnerability for therapeutic exploitation. The presence of replication stress activates the DNA damage response and downstream checkpoint proteins including ataxia telangiectasia and Rad3 related kinase...

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PMID: 32571890
DOI: 10.1136/ijgc-2020-001277

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