Article

EZH2 inhibition remodels the inflammatory senescence-associated secretory phenotype to potentiate pancreatic cancer immune surveillance

2022-06-23

Abstract excerpt

<h4>ABSTRACT</h4> T cell-activating immunotherapies that produce durable and even curative responses in some malignancies have failed in pancreatic ductal adenocarcinoma (PDAC) due to rampant immune suppression and poor tumor immunogenicity. We and others have demonstrated that induction of cellular senescence and its accompanying senescence-associated secretory phenotype (SASP) can be an effective approach to ac...

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Literature Corpus work: 0d6fe6a7-e765-541e-8d7b-a8e77eb85684
DOI: 10.1101/2022.06.21.495523

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