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Article

Autophagy contributes to therapy-induced degradation of the PML/RARA oncoprotein

24 Jun 2010

Abstract excerpt

Treatment of acute promyelocytic leukemia (APL) with all-trans retinoic acid and/or arsenic trioxide represents a paradigm in targeted cancer therapy because these drugs cause clinical remission by affecting the stability of the fusion oncoprotein promyelocytic leukemia (PML)/retinoic acid receptor alpha (RARA). The authors of previous studies have implicated the ubiquitin-proteasome pathway as the main mechanism...

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PMID: 20574048
DOI: 10.1182/blood-2010-01-261040

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