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Article

PML-RARα enhances constitutive autophagic activity through inhibiting the Akt/mTOR pathway

1 Oct 2011

Abstract excerpt

Autophagy is a highly conserved, closely regulated homeostatic cellular activity that allows for the bulk degradation of long-lived proteins and cytoplasmic organelles. Its roles in cancer initiation and progression and in determining the response of tumor cells to anticancer therapy are complicated, and only limited investigation has been conducted on the potential significance of autophagy in the pathogenesis...

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PMID: 21673516
DOI: 10.4161/auto.7.10.16636

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