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Article

DNA Repair and Resistance of Gliomas to Chemotherapy and Radiotherapy

1 Jul 2009

Abstract excerpt

The importance of DNA repair as a resistance mechanism in gliomas, the most aggressive form of brain tumor, is a clinically relevant topic. Recent studies show that not all cells are equally malignant in gliomas. Certain subpopulations are particularly prone to drive tumor progression and resist chemo- and radiotherapy. Those cells have been variably named cancer stem cells or cancer-initiating cells or...

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PMID: 19609002
DOI: 10.1158/1541-7786.mcr-09-0030

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