Article
DNA damage response in brain tumors: A Society for Neuro-Oncology consensus review on mechanisms and translational efforts in neuro-oncology.
Neuro-oncology - 5 Aug 2024
Rahman Rifaquat, Shi Diana D, Reitman Zachary J, Hamerlik Petra, de Groot John F, Haas-Kogan Daphne A, D'Andrea Alan D, Sulman Erik P, Tanner Kirk, Agar Nathalie Y R, Sarkaria Jann N, Tinkle Christopher L, Bindra Ranjit S, Mehta Minesh P, Wen Patrick Y
Abstract excerpt
DNA damage response (DDR) mechanisms are critical to maintenance of overall genomic stability, and their dysfunction can contribute to oncogenesis. Significant advances in our understanding of DDR pathways have raised the possibility of developing therapies that exploit these processes. In this expert-driven consensus review, we examine mechanisms of response to DNA damage, progress in development of DDR...
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