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Article

DNA Damage Response and Repair: Insights Into Strategies for Radiation Sensitization of Gliomas

1 Nov 2011

Abstract excerpt

The incorporation of radiotherapy into multimodality treatment plans has led to significant improvements in glioma patient survival. However, local recurrence from glioma resistance to ionizing radiation remains a therapeutic challenge. The tumoricidal effect of radiation therapy is largely attributed to the induction of dsDNA breaks (DSBs). In the past decade, there have been tremendous strides in understanding...

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Identifiers

PMID: 22044206
DOI: 10.2217/fon.11.111

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