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Chemotherapeutic Drugs: DNA Damage and Repair in Glioblastoma

26 May 2017

Abstract excerpt

Despite improvements in therapeutic strategies, glioblastoma (GB) remains one of the most lethal cancers. The presence of the blood-brain barrier, the infiltrative nature of the tumor and several resistance mechanisms account for the failure of current treatments. Distinct DNA repair pathways can neutralize the cytotoxicity of chemo- and radio-therapeutic agents, driving resistance and tumor relapse. It seems...

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Cancer therapeutics and mechanisms
DNA Repair Mechanisms
Glioma Diagnosis and Treatment

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 28587121
DOI: 10.3390/cancers9060057

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