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Article

DNA Damage Response and Growth Factor Signaling Pathways in Gliomagenesis and Therapeutic Resistance

13 Sept 2011

Abstract excerpt

The dismal prognosis of glioblastoma multiforme (GBM) is mainly due to the poor response of GBM patients to any therapeutic modalities, which include ionizing radiation and DNA-alkylating agents. In the last few years, the important role of the DNA damage response (DDR) pathway in tumor formation and modulation of therapeutic response has been appreciated. Interestingly, several of the genetic alterations...

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PMID: 21917735
DOI: 10.1158/0008-5472.can-11-1245

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