Article
CHRNA5 risk variant predicts delayed smoking cessation and earlier lung cancer diagnosis--a meta-analysis.
Journal of the National Cancer Institute - 1 May 2015
Chen Li-Shiun, Hung Rayjean J, Baker Timothy, Horton Amy, Culverhouse Rob, Saccone Nancy, Cheng Iona, Deng Bo, Han Younghun, Hansen Helen M, Horsman Janet, Kim Claire, Lutz Sharon, Rosenberger Albert, Aben Katja K, Andrew Angeline S, Breslau Naomi, Chang Shen-Chih, Dieffenbach Aida Karina, Dienemann Hendrik, Frederiksen Brittni, Han Jiali, Hatsukami Dorothy K, Johnson Eric O, Pande Mala, Wrensch Margaret R, McLaughlin John, Skaug Vidar, van der Heijden Henricus F, Wampfler Jason, Wenzlaff Angela, Woll Penella, Zienolddiny Shanbeh, Bickeböller Heike, Brenner Hermann, Duell Eric J, Haugen Aage, Heinrich Joachim, Hokanson John E, Hunter David J, Kiemeney Lambertus A, Lazarus Philip, Le Marchand Loic, Liu Geoffrey, Mayordomo Jose, Risch Angela, Schwartz Ann G, Teare Dawn, Wu Xifeng, Wiencke John K, Yang Ping, Zhang Zuo-Feng, Spitz Margaret R, Kraft Peter, Amos Christopher I, Bierut Laura J
Abstract excerpt
BACKGROUND: Recent meta-analyses show strong evidence of associations among genetic variants in CHRNA5 on chromosome 15q25, smoking quantity, and lung cancer. This meta-analysis tests whether the CHRNA5 variant rs16969968 predicts age of smoking cessation and age of lung cancer diagnosis. METHODS: Meta-analyses examined associations between rs16969968, age of quitting smoking, and age of lung cancer diagnosis in...
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