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Tumor-associated carbohydrate antigens of MUC1 – Implication in cancer development

20 Apr 2024

Abstract excerpt

Glycosylation of cancerous epithelial MUC1 protein is specifically altered in comparison to that which is presented by healthy cells. One of such changes is appearing tumor-associated carbohydrate antigens (TACAs) which are rare in normal tissues and are highly correlated with poor clinical outcomes and cancer progression. This review summarizes and describes the role of Tn, T antigens, their sialylated forms as...

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PMID: 38643541
DOI: 10.1016/j.biopha.2024.116619

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