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Article

O-linked mucin-type glycosylation regulates the transcriptional programme downstream of EGFR in breast cancer

2019-07-25

Abstract excerpt

<h4>ABSTRACT</h4> Aberrant mucin type O-linked glycosylation is a common occurrence in cancer. This type of O-linked glycosylation is not limited to mucins but can occur on many cell surface glycoproteins where only a small number of sites may be present. Upon EGF ligation, EGFR induces a signaling cascade but can also translocate to the nucleus where it can directly regulate gene transcription. Here we show that...

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Literature Corpus work
c9185fc6-bcbf-520e-b37a-6819ca269c01
DOI
10.1101/714675
Open publication

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O-linked mucin-type glycosylation regulates the transcriptional programme downstream of EGFR in breast cancerDOI 10.1101/714675
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