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Article

Orphan nuclear receptors as regulators of intratumoral androgen biosynthesis in castration-resistant prostate cancer

9 Mar 2021

Abstract excerpt

Castration-resistant prostate cancer (CRPC) almost invariably occurs after androgen-deprivation therapy (ADT) for the advanced metastatic disease. It is generally believed that among multiple mechanisms and signaling pathways, CRPC is significantly driven by the reactivation of androgen receptor (AR) signaling in ADT-treated patients with castrate levels of androgen, partially at least mediated by the androgen...

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Share to Cancer, Lipids, and Metabolism
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PMID: 33750894
DOI: 10.1038/s41388-021-01737-1

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