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Article

Mutations at the Subunit Interface of Yeast Proliferating Cell Nuclear Antigen Reveal a Versatile Regulatory Domain.

PloS one - 1 Jan 2016

Halmai Miklos, Frittmann Orsolya, Szabo Zoltan, Daraba Andreea, Gali Vamsi K, Balint Eva, Unk Ildiko

Abstract excerpt

Proliferating cell nuclear antigen (PCNA) plays a key role in many cellular processes and due to that it interacts with a plethora of proteins. The main interacting surfaces of Saccharomyces cerevisiae PCNA have been mapped to the interdomain connecting loop and to the carboxy-terminal domain. Here we report that the subunit interface of yeast PCNA also has regulatory roles in the function of several DNA damage...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 27537501
DOI: 10.1371/journal.pone.0161307
PMCID: PMC4990258

Genes

PCNA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

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Mutations at the Subunit Interface of Yeast Proliferating Cell Nuclear Antigen Reveal a Versatile Regulatory Domain.PMID 27537501Read ↗

Identification of New Mutations at the PCNA Subunit Interface that Block Translesion Synthesis.Semantic proximity Read ↗

The non-canonical protein binding site at the monomer-monomer interface of yeast proliferating cell nuclear antigen (PCNA) regulates the Rev1-PCNA interaction and Polζ/Rev1-dependent translesion DNA synthesis.Semantic proximity Read ↗

The PCNA interaction protein box sequence in Rad54 is an integral part of its ATPase domain and is required for efficient DNA repair and recombination.Semantic proximity Read ↗

In vivo analysis reveals that the interdomain region of the yeast proliferating cell nuclear antigen is important for DNA replication and DNA repair.Semantic proximity Read ↗

Mutations in yeast proliferating cell nuclear antigen define distinct sites for interaction with DNA polymerase delta and DNA polymerase epsilon.Semantic proximity Read ↗

Crystal structures of PCNA mutant proteins defective in gene silencing suggest a novel interaction site on the front face of the PCNA ring.Semantic proximity Read ↗

Structure of a mutant form of proliferating cell nuclear antigen that blocks translesion DNA synthesis.Semantic proximity Read ↗

A charged residue at the subunit interface of PCNA promotes trimer formation by destabilizing alternate subunit interactions.Semantic proximity Read ↗

Something's gotta give: How PCNA alters its structure in response to mutations and the implications on cellular processes.Semantic proximity Read ↗

Subtle alterations in PCNA-partner interactions severely impair DNA replication and repair.Semantic proximity Read ↗

Direct interaction between uracil-DNA glycosylase and a proliferating cell nuclear antigen homolog in the crenarchaeon Pyrobaculum aerophilum.Semantic proximity Read ↗

A mutational analysis of the yeast proliferating cell nuclear antigen indicates distinct roles in DNA replication and DNA repair.Semantic proximity Read ↗

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