Article
Identification of New Mutations at the PCNA Subunit Interface that Block Translesion Synthesis.
PloS one - 1 Jan 2016
Kondratick Christine M, Boehm Elizabeth M, Dieckman Lynne M, Powers Kyle T, Sanchez Julio C, Mueting Samuel R, Washington M Todd
Abstract excerpt
Proliferating cell nuclear antigen (PCNA) plays an essential role in DNA replication and repair by interacting with a large number of proteins involved in these processes. Two amino acid substitutions in PCNA, both located at the subunit interface, have previously been shown to block translesion synthesis (TLS), a pathway for bypassing DNA damage during replication. To better understand the role of the subunit...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.