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Article

A charged residue at the subunit interface of PCNA promotes trimer formation by destabilizing alternate subunit interactions.

Acta crystallographica. Section D, Biological crystallography - 1 Jun 2009

Freudenthal Bret D, Gakhar Lokesh, Ramaswamy S, Washington M Todd

Abstract excerpt

Eukaryotic proliferating cell nuclear antigen (PCNA) is an essential replication accessory factor that interacts with a variety of proteins involved in DNA replication and repair. Each monomer of PCNA has an N-terminal domain A and a C-terminal domain B. In the structure of the wild-type PCNA protein, domain A of one monomer interacts with domain B of a neighboring monomer to form a ring-shaped trimer. Glu113 is...

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Identifiers

PMID: 19465770
DOI: 10.1107/S0907444909011329
PMCID: PMC2685733

Genes

PCNA

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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A charged residue at the subunit interface of PCNA promotes trimer formation by destabilizing alternate subunit interactions.PMID 19465770Read ↗

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