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Article

Structure of a mutant form of proliferating cell nuclear antigen that blocks translesion DNA synthesis.

Biochemistry - 16 Dec 2008

Freudenthal Bret D, Ramaswamy S, Hingorani Manju M, Washington M Todd

Abstract excerpt

Proliferating cell nuclear antigen (PCNA) is a homotrimeric protein that functions as a sliding clamp during DNA replication. Several mutant forms of PCNA that block translesion DNA synthesis have been identified in genetic studies in yeast. One such mutant protein (encoded by the rev6-1 allele) is a glycine to serine substitution at residue 178, located at the subunit interface of PCNA. To improve our...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 19053247
DOI: 10.1021/bi8017762
PMCID: PMC2703463

Genes

PCNA

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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