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Article

Tropomodulin 1 Regulation of Actin Is Required for the Formation of Large Paddle Protrusions Between Mature Lens Fiber Cells.

Investigative ophthalmology & visual science - 1 Aug 2016

Cheng Catherine, Nowak Roberta B, Biswas Sondip K, Lo Woo-Kuen, FitzGerald Paul G, Fowler Velia M

Abstract excerpt

PURPOSE: To elucidate the proteins required for specialized small interlocking protrusions and large paddle domains at lens fiber cell tricellular junctions (vertices), we developed a novel method to immunostain single lens fibers and studied changes in cell morphology due to loss of tropomodulin 1 (Tmod1), an F-actin pointed end-capping protein. METHODS: We investigated F-actin and F-actin-binding protein...

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Identifiers

PMID: 27537257
DOI: 10.1167/iovs.16-19949
PMCID: PMC4986768

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Source receipt: pubmed, retrieved 7 Sept 2026.

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