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SiNVICT: ultra-sensitive detection of single nucleotide variants and indels in circulating tumour DNA

16 Aug 2016

Abstract excerpt

MOTIVATION: Successful development and application of precision oncology approaches require robust elucidation of the genomic landscape of a patient's cancer and, ideally, the ability to monitor therapy-induced genomic changes in the tumour in an inexpensive and minimally invasive manner. Thanks to recent advances in sequencing technologies, 'liquid biopsy', the sampling of patient's bodily fluids such as blood...

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PMID: 27531099
DOI: 10.1093/bioinformatics/btw536

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