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Article

SinoDuplex: An Improved Duplex Sequencing Approach to Detect Low-frequency Variants in Plasma cfDNA Samples.

Genomics, proteomics & bioinformatics - 1 Feb 2020

Ren Yongzhe, Zhang Yang, Wang Dandan, Liu Fengying, Fu Ying, Xiang Shaohua, Su Li, Li Jiancheng, Dai Heng, Huang Bingding

Abstract excerpt

Accurate detection of low frequency mutations from plasma cell-free DNA in blood using targeted next generation sequencing technology has shown promising benefits in clinical settings. Duplex sequencing technology is the most commonly used approach in liquid biopsies. Unique molecular identifiers are attached to each double-stranded DNA template, followed by production of low-error consensus sequences to detect...

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Identifiers

PMID: 32428603
DOI: 10.1016/j.gpb.2020.02.003
PMCID: PMC7393544

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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