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Article

PACT: a pipeline for analysis of circulating tumor DNA.

Bioinformatics (Oxford, England) - 1 Aug 2023

Webster Jace, Dang Ha X, Chauhan Pradeep S, Feng Wenjia, Shiang Alex, Harris Peter K, Pachynski Russell K, Chaudhuri Aadel A, Maher Christopher A

Abstract excerpt

MOTIVATION: Detection of genomic alterations in circulating tumor DNA (ctDNA) is currently used for active clinical monitoring of cancer progression and treatment response. While methods for analysis of small mutations are more developed, strategies for detecting structural variants (SVs) in ctDNA are limited. Additionally, reproducibly calling small-scale mutations, copy number alterations, and SVs in ctDNA is...

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Identifiers

PMID: 37549060
DOI: 10.1093/bioinformatics/btad489
PMCID: PMC10415172

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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