Article
Allele-Independent Turnover of Human Leukocyte Antigen (HLA) Class Ia Molecules.
PloS one - 1 Jan 2016
Prevosto Claudia, Usmani M Farooq, McDonald Sarah, Gumienny Aleksandra M, Key Tim, Goodman Reyna S, Gaston J S Hill, Deery Michael J, Busch Robert
Abstract excerpt
Major histocompatibility complex class I (MHCI) glycoproteins present cytosolic peptides to CD8+ T cells and regulate NK cell activity. Their heavy chains (HC) are expressed from up to three MHC gene loci (human leukocyte antigen [HLA]-A, -B, and -C in humans), whose extensive polymorphism maps predominantly to the antigen-binding groove, diversifying the bound peptide repertoire. Codominant expression of MHCI...
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