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Article

The nature and extent of contributions by defective ribosome products to the HLA peptidome

8 Apr 2014

Abstract excerpt

MHC class I peptides are products of endogenous cellular protein degradation. Their prompt presentation, after rapid degradation of their newly synthesized source proteins, is needed to alert the immune system during pathogen infection. A possible source for such rapidly degrading proteins can be defective ribosome products (DRiPs), which include polypeptides produced as part of the pioneer round of translation,...

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PMID: 24715725
DOI: 10.1073/pnas.1321902111

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