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Article

Association of TP53 and CDKN2A Mutation Profile with Tumor Mutation Burden in Head and Neck Cancer.

Clinical cancer research : an official journal of the American Association for Cancer Research - 2 May 2022

Deneka Alexander Y, Baca Yasmine, Serebriiskii Ilya G, Nicolas Emmanuelle, Parker Mitchell I, Nguyen Theodore T, Xiu Joanne, Korn W Michael, Demeure Michael J, Wise-Draper Trisha, Sukari Ammar, Burtness Barbara, Golemis Erica A

Abstract excerpt

PURPOSE: Head and neck squamous cell carcinoma (HNSCC) is a frequently devastating cancer that affects more than a half million people annually worldwide. Although some cases arise from infection with human papillomavirus (HPV), HPV-negative HNSCC is more common, and associated with worse outcome. Advanced HPV-negative HNSCC may be treated with surgery, chemoradiation, targeted therapy, or immune checkpoint...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cyclin-Dependent Kinase Inhibitor p16

Share to Head and Neck Neoplasms

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Share to Papillomavirus Infections

Share to Squamous Cell Carcinoma of Head and Neck

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Source

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Identifiers

PMID: 35491653
DOI: 10.1158/1078-0432.CCR-21-4316
PMCID: PMC9186806

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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