Article
TNF receptors 1 and 2 exert distinct region-specific effects on striatal and hippocampal grey matter volumes (VBM) in healthy adults.
Genes, brain, and behavior - 1 Mar 2017
Stacey D, Redlich R, Büschel A, Opel N, Grotegerd D, Zaremba D, Dohm K, Bürger C, Meinert S L, Förster K, Repple J, Kaufmann C, Kugel H, Heindel W, Arolt V, Dannlowski U, Baune B T
Abstract excerpt
Tumour necrosis factor alpha (TNFα) has been implicated in the pathophysiology of neurodegenerative and neuropsychiatric disease, with research highlighting a role for TNFα in hippocampal and striatal regulation. TNFα signals are primarily transduced by TNF receptors 1 and 2 (TNFR1 and TNFR2), encoded by TNFRSF1A and TNFRSF1B, which exert opposing effects on cell survival (TNFR1, neurodegenerative; TNFR2,...
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