Article

Side Chain-modified Benzothiazinone Derivatives with Anti-Mycobacterial Activity

2023-06-01

Abstract excerpt

Tuberculosis (TB) is a leading infectious disease with serious antibiotic resistance. The benzothiazinone (BTZ) scaffold PBTZ169, an inhibitor of the decaprenylphosphoryl-β-D-ribose 2'-oxidase (DprE1) in Mycobacterium tuberculosis (Mtb), showed anti-TB potential in animal model and piloted clinical tests. Although highly potent, the BTZ type DprE1 inhibitors in general shows extremely low aqueous solubility,...

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Literature Corpus work: 74007a55-4dbb-5bb9-9857-3d4b1904f126
DOI: 10.20944/preprints202305.1839.v2

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