Article
Allostimulatory Effects of Dendritic Cells with Characteristic Features of a Regulatory Phenotype.
PloS one - 1 Jan 2016
Kouwenberg M, Jacobs C W M, van der Vlag J, Hilbrands L B
Abstract excerpt
INTRODUCTION: Tolerogenic dendritic cells (DCs) have the potential to prolong graft survival after transplantation. Tolerogenic DCs are in general characterized by a low expression of co-stimulatory molecule and a high IL-10:IL-12 production ratio. Based on promising results with earlier used alternatively activated DCs, we aimed to generate in culture potentially tolerogenic DC by simultaneously blocking GSK3 by...
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