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Article

Clusterin: a marker and mediator of chemoresistance in colorectal cancer

6 Feb 2024

Abstract excerpt

Abstract Intra-tumoural heterogeneity and cancer cell plasticity in colorectal cancer (CRC) have been key challenges to effective treatment for patients. It has been suggested that a subpopulation of LGR5-expressing cancer stem cells (CSCs) is responsible for driving tumour relapse and therapy resistance in CRC. However, studies have revealed that the LGR5+ve CSC population is highly sensitive to chemotherapy. It...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 38319453
DOI: 10.1007/s10555-024-10173-y

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