Article
Development and experimental validation of computational methods for human antibody affinity enhancement.
Briefings in bioinformatics - 23 Sept 2024
Li Junxin, Liao Linbu, Zhang Chao, Huang Kaifang, Zhang Pengfei, Zhang John Z H, Wan Xiaochun, Zhang Haiping
Abstract excerpt
High affinity is crucial for the efficacy and specificity of antibody. Due to involving high-throughput screens, biological experiments for antibody affinity maturation are time-consuming and have a low success rate. Precise computational-assisted antibody design promises to accelerate this process, but there is still a lack of effective computational methods capable of pinpointing beneficial mutations within the...
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