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Article

New insights into the effect of mutations on affibody-Fc interaction, a molecular dynamics simulation approach.

Journal of structural biology - 1 Mar 2023

Nosrati Masoumeh, Housaindokht Mohammad Reza

Abstract excerpt

Staphylococcal protein A (SpA) domain B (the basis of affibody) has been widely used in affinity chromatography and found therapeutic applications against inflammatory diseases through targeting the Fc part of immunoglobulin G (IgG). We have performed extensive molecular dynamics simulation of 41 SpA mutants and compared their dynamics and conformations to wild type. The simulations revealed the molecular details...

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Identifiers

PMID: 36470559
DOI: 10.1016/j.jsb.2022.107925

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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