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Article

Computational designing of the ligands of Protein L affinity chromatography based on molecular docking and molecular dynamics simulations.

Journal of biomolecular structure & dynamics - 1 Jan 2024

Rahmati Saman, Bagherzadeh Kowsar, Arab Seyed Shahriar, Torkashvand Fatemeh, Amanlou Massoud, Vaziri Behrouz

Abstract excerpt

Protein L is a multidomain protein from Peptostreptococcus magnus with binding affinity to kappa light chain of human immunoglobulin (Ig) which is used for the purification of antibody fragments by affinity chromatography. The advances in protein engineering and computational biology approaches lead to the development of engineered affinity ligands with improved properties including binding affinity. In this...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 37855377
DOI: 10.1080/07391102.2023.2268219

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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