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Article

Heterodimerization of the kappa opioid receptor and neurotensin receptor 1 contributes to a novel β-arrestin-2-biased pathway.

Biochimica et biophysica acta - 1 Nov 2016

Liu Haiqing, Tian Yanjun, Ji Bingyuan, Lu Hai, Xin Qing, Jiang Yunlu, Ding Liangcai, Zhang Jingmei, Chen Jing, Bai Bo

Abstract excerpt

Together with its endogenous ligands (dynorphin), the kappa opioid receptor (KOR) plays an important role in modulating various physiological and pharmacological responses, with a classical G protein-coupled pathway mediating analgesia and non-G protein-dependent pathway, especially the β-arrestin-dependent pathway, eliciting side effects of dysphoria, aversion, drug-seeking in addicts, or even relapse to...

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PMID: 27523794
DOI: 10.1016/j.bbamcr.2016.07.009

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NTSR1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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