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Article

Opioid Addiction and Opioid Receptor Dimerization: Structural Modeling of the OPRD1 and OPRM1 Heterodimer and Its Signaling Pathways.

International journal of molecular sciences - 24 Sept 2021

Wu Bohua, Hand William, Alexov Emil

Abstract excerpt

Opioid addiction is a complex phenomenon with genetic, social, and other components. Due to such complexity, it is difficult to interpret the outcome of clinical studies, and thus, mutations found in individuals with these addictions are still not indisputably classified as opioid addiction-causing variants. Here, we computationally investigated two such mutations, A6V and N40D, found in the mu opioid receptor...

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Source

Open in PubMed Open full text

Identifiers

PMID: 34638633
DOI: 10.3390/ijms221910290
PMCID: PMC8509015

Genes

OPRM1
OPRD1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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