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Article

Aquaporin 2 mutations in Trypanosoma brucei gambiense field isolates correlate with decreased susceptibility to pentamidine and melarsoprol.

PLoS neglected tropical diseases - 1 Jan 2013

Graf Fabrice E, Ludin Philipp, Wenzler Tanja, Kaiser Marcel, Brun Reto, Pyana Patient Pati, Büscher Philippe, de Koning Harry P, Horn David, Mäser Pascal

Abstract excerpt

The predominant mechanism of drug resistance in African trypanosomes is decreased drug uptake due to loss-of-function mutations in the genes for the transporters that mediate drug import. The role of transporters as determinants of drug susceptibility is well documented from laboratory-selected Trypanosoma brucei mutants. But clinical isolates, especially of T. b. gambiense, are less amenable to experimental...

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PMID: 24130910
DOI: 10.1371/journal.pntd.0002475
PMCID: PMC3794916

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