Identification of a genetic marker for isometamidium chloride resistance in Trypanosoma congolense.

doi:10.1016/j.ijpara.2004.11.009

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Article

Identification of a genetic marker for isometamidium chloride resistance in Trypanosoma congolense.

International journal for parasitology - 1 Feb 2005

Delespaux V, Geysen D, Majiwa Phelix A O, Geerts S

Abstract excerpt

Isometamidium chloride has remained a very important prophylactic and therapeutic drug against trypanosomosis in cattle since its introduction into the market in the 1950s with, unfortunately, a concomitant development of resistance in trypanosomosis endemic areas. Amplified Fragment Length Polymorphism (AFLP) was used to compare two isogenic clones of Trypanosoma congolense. The parent clone, sensitive to...

Topics

ATP-Binding Cassette Transporters
Amino Acid Sequence
Animals
Base Sequence
Cattle
DNA, Protozoan
Drug Resistance
Gene Amplification
Genetic Markers
Genome, Protozoan
Mice

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Molecular Sequence Data

Phenanthridines

Phenotype

Polymorphism, Genetic

Polymorphism, Restriction Fragment Length

Sequence Homology, Nucleic Acid

Trypanocidal Agents

Source

Open in PubMed

Identifiers

PMID: 15710444
DOI: 10.1016/j.ijpara.2004.11.009

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