Article

Kinetoplastid diseases: Insights into the mechanisms of drug action and resistance for novel drug discovery

2025-03-05

Abstract excerpt

Trypanosoma and Leishmania species are kinetoplastid protozoan parasites that cause diseases which result in significant disability-adjusted life years (DALYs) and agricultural losses in the developing world. Despite the progress recorded in understanding biology and chemotherapy of these pathogens of neglected diseases, treatment failure, due to drug resistance or toxicity-driven non-compliance remain major chall...

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Literature Corpus work: 019c8d62-452f-59ff-89db-fa561324c0e2
DOI: 10.1016/j.amolm.2025.100071

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