Article
Identification of the RNA polymerase II subunit hsRPB7 as a novel target of the von Hippel-Lindau protein.
The EMBO journal - 15 Aug 2003
Na Xi, Duan Hai Ou, Messing Edward M, Schoen Susan R, Ryan Charlotte K, di Sant'Agnese P Anthony, Golemis Erica A, Wu Guan
Abstract excerpt
Inactivation of the von Hippel-Lindau (VHL) tumor suppressor gene is linked to the hereditary VHL disease and sporadic clear cell renal cell carcinomas (CCRCC). VHL-associated tumors are highly vascularized, a characteristic associated with overproduction of vascular endothelial growth factor (VEGF). The VHL protein (pVHL) is a component of the ubiquitin ligase E3 complex, targeting substrate proteins for...
Topics
- Cell Nucleus
- Cysteine Endopeptidases
- Endothelial Growth Factors
- Gene Expression Regulation, Neoplastic
- HeLa Cells
- Humans
- Intercellular Signaling Peptides and Proteins
- Kidney Neoplasms
- Lymphokines
- Multienzyme Complexes