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Article

Identification of the RNA polymerase II subunit hsRPB7 as a novel target of the von Hippel-Lindau protein.

The EMBO journal - 15 Aug 2003

Na Xi, Duan Hai Ou, Messing Edward M, Schoen Susan R, Ryan Charlotte K, di Sant'Agnese P Anthony, Golemis Erica A, Wu Guan

Abstract excerpt

Inactivation of the von Hippel-Lindau (VHL) tumor suppressor gene is linked to the hereditary VHL disease and sporadic clear cell renal cell carcinomas (CCRCC). VHL-associated tumors are highly vascularized, a characteristic associated with overproduction of vascular endothelial growth factor (VEGF). The VHL protein (pVHL) is a component of the ubiquitin ligase E3 complex, targeting substrate proteins for...

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Source

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Identifiers

PMID: 12912922
DOI: 10.1093/emboj/cdg410
PMCID: PMC175799

Genes

VHL

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Identification of the RNA polymerase II subunit hsRPB7 as a novel target of the von Hippel-Lindau protein.PMID 12912922Read ↗

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Recent advances in etiology and treatment of von Hippel-Lindau Disease (VHLD).Semantic proximity Read ↗

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