Article
Deubiquitylase OTUD6B stabilizes the mutated pVHL and suppresses cell migration in clear cell renal cell carcinoma.
Cell death & disease - 2 Feb 2022
Guo Kai, Wei Yinghua, Wang Ze, Zhang Xiaoli, Zhang Xin, Liu Xinxin, Wu Wenyong, Wu Zhengsheng, Zhang Lingqiang, Cui Chun-Ping
Abstract excerpt
Von Hippel-Lindau (VHL) is an important tumor suppressor, and its inactivation is a hallmark of inherited VHL disease and most sporadic clear cell renal cell carcinoma (ccRCC). VHL protein (pVHL) with missense point mutations are unstable and degraded by the proteasome because of the disruption of elongin binding. Deubiquitylase ovarian tumor domain-containing 6B (OTUD6B) had been documented to couple pVHL and...
Topics
- Carcinoma, Renal Cell
- Cell Line, Tumor
- Cell Movement
- Endopeptidases
- Humans
- Kidney Neoplasms
- Mutation
- Prognosis
- Protein Binding
- Protein Stability
- Ubiquitination