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Article

The von Hippel-Lindau tumor suppressor protein is a component of an E3 ubiquitin-protein ligase activity.

Genes & development - 15 Jul 1999

Lisztwan J, Imbert G, Wirbelauer C, Gstaiger M, Krek W

Abstract excerpt

pVHL, the product of the VHL tumor suppressor gene, plays an important role in the regulation of cell growth and differentiation of human kidney cells, and inactivation of the VHL gene is the most frequent genetic event in human kidney cancer. The biochemical function of pVHL is unknown. Here we report that pVHL exists in vivo in a complex that displays ubiquitination-promoting activity in conjunction with the...

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Source

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Identifiers

PMID: 10421634
DOI: 10.1101/gad.13.14.1822
PMCID: PMC316884

Genes

VHL

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

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The von Hippel-Lindau tumor suppressor protein is a component of an E3 ubiquitin-protein ligase activity.PMID 10421634Read ↗

Identification of the von Hippel-lindau tumor-suppressor protein as part of an active E3 ubiquitin ligase complex.Semantic proximity Read ↗

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Conjugation of the ubiquitin-like protein NEDD8 to cullin-2 is linked to von Hippel-Lindau tumor suppressor function.Semantic proximity Read ↗

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USP9X destabilizes pVHL and promotes cell proliferation.Semantic proximity Read ↗

The von Hippel-Lindau tumor-suppressor gene product forms a stable complex with human CUL-2, a member of the Cdc53 family of proteinsSemantic proximity Read ↗

Recent advances in etiology and treatment of von Hippel-Lindau Disease (VHLD).Semantic proximity Read ↗

The Von Hippel-Lindau Tumor Suppressor Gene and Kidney CancerSemantic proximity Read ↗

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Identification of the RNA polymerase II subunit hsRPB7 as a novel target of the von Hippel-Lindau protein.Semantic proximity Read ↗

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von Hippel-Lindau protein mutants linked to type 2C VHL disease preserve the ability to downregulate HIF.Semantic proximity Read ↗

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