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Article

Ubiquitination of a novel deubiquitinating enzyme requires direct binding to von Hippel-Lindau tumor suppressor protein.

The Journal of biological chemistry - 15 Feb 2002

Li Zaibo, Na Xi, Wang Dakun, Schoen Susan R, Messing Edward M, Wu Guan

Abstract excerpt

von Hippel-Lindau (VHL) disease is a hereditary cancer syndrome caused by germline mutations of the VHL gene. Recent studies suggest that VHL protein (pVHL) is a component of an E3 ubiquitin ligase, but the detailed biological function of pVHL remains to be determined. To further elucidate the biological functions of pVHL, we searched pVHL-interacting proteins using yeast two-hybrid screening. A novel protein...

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Identifiers

PMID: 11739384
DOI: 10.1074/jbc.M108269200

Genes

VHL

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Ubiquitination of a novel deubiquitinating enzyme requires direct binding to von Hippel-Lindau tumor suppressor protein.PMID 11739384Read ↗

The von Hippel-Lindau tumor suppressor protein is a component of an E3 ubiquitin-protein ligase activity.Semantic proximity Read ↗

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Conjugation of the ubiquitin-like protein NEDD8 to cullin-2 is linked to von Hippel-Lindau tumor suppressor function.Semantic proximity Read ↗

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Identification of the RNA polymerase II subunit hsRPB7 as a novel target of the von Hippel-Lindau protein.Semantic proximity Read ↗

von Hippel-Lindau DiseaseSemantic proximity Read ↗

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