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Alterations of tumor suppressor and tumor-related genes in the development and progression of gastric cancer

1 Jan 2006

Abstract excerpt

The development and progression of gastric cancer involves a number of genetic and epigenetic alterations of tumor suppressor and tumor-related genes. The majority of differentiated carcinomas arise from intestinal metaplastic mucosa and exhibit structurally altered tumor suppressor genes, typified by p53, which is inactivated via the classic two-hit mechanism, i.e. loss of heterozygosity (LOH) and mutation of...

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PMID: 16482617
DOI: 10.3748/wjg.v12.i2.192

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Source receipt: pubmed, retrieved 7 Sept 2026.

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