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Article

High-definition CpG methylation of novel genes in gastric carcinogenesis identified by next-generation sequencing.

Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc - 1 Feb 2016

Sepulveda Jorge L, Gutierrez-Pajares Jorge L, Luna Aesis, Yao Yuan, Tobias John W, Thomas Steven, Woo Yanghee, Giorgi Federico, Komissarova Elena V, Califano Andrea, Wang Timothy C, Sepulveda Antonia R

Abstract excerpt

Gastric cancers are the most frequent gastric malignancy and usually arise in the sequence of Helicobacter pylori-associated chronic gastritis. CpG methylation is a central mechanism of epigenetic gene regulation affecting cancer-related genes, and occurs early in gastric carcinogenesis. DNA samples from non-metaplastic gastric mucosa with variable levels of gastritis (non-metaplastic mucosa), intestinal...

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Topics

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Share to Cell Transformation, Neoplastic
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 26769141
DOI: 10.1038/modpathol.2015.144

Genes

FLI1
SGCE
BRINP1
GALR1
SNRPN
CDH11
CHFR
EPHA5
EPHA7
FGF2
PDGFRA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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