Article
The Tumor-Associated Variant RAD51 G151D Induces a Hyper-Recombination Phenotype.
PLoS genetics - 1 Aug 2016
Marsden Carolyn G, Jensen Ryan B, Zagelbaum Jennifer, Rothenberg Eli, Morrical Scott W, Wallace Susan S, Sweasy Joann B
Abstract excerpt
The RAD51 protein plays a key role in the homology-directed repair of DNA double-strand breaks and is important for maintaining genome stability. Here we report on a novel human RAD51 variant found in an aggressive and therapy-refractive breast carcinoma. Expression of the RAD51 G151D variant in human breast epithelial cells increases the levels of homology-directed repair. Expression of RAD51 G151D in cells also...
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